Epidemiological studies

PREDIMED is a randomized, controlled, multi-center, parallel group clinical trial aimed at evaluating the effects of the Mediterranean Diet on the primary prevention of cardiovascular disease.

Due to the results of the PREDIMED study, in 2013 it was decided to carry out another complementary study, called PREDIMED PLUS, in order to assess the effect of a multifactorial intervention on the reduction of cardiovascular morbidity and mortality in adults over 55 years with overweight and obesity. This study consists of carrying out an intensive intervention, based on the consumption of a low calorie Mediterranean diet, supplemented with extra virgin olive oil and nuts, in addition to promoting physical activity and behavioral therapy.

EPIC (European Prospective Investigation into Cancer) is an observational epidemiological study to learn more about the relationship between nutrition and cancer, thus integrating epidemiology and laboratory investigations, analyzing genetic and metabolic factors. It has 40,885 volunteers (61.7% women) recruited in 5 geographic areas of Spain: Asturias, Granada, Guipúzcoa, Murcia and Navarra.

Together with other researchers, we are part of the  Programa de Salud Integral SI! secundaria that seeks to promote healthier eating habits and behaviors in early stages of life, such as adolescence. This study (NCT03504059), is a group randomized controlled trial involving 24 secondary schools in Spain (1366 participants), and lasts for 4 years (2017 to 2021). We hope to show that there are favorable changes in cardiovascular health as a result of educational intervention at school. In addition, establish associations of health parameters with the intake of bioactive compounds from the diet and metabolic profiles.